The U.S. Preventive Services Task Force (USPSTF) recommends against the use of combined estrogen and progestin for the prevention of chronic conditions in postmenopausal women. This recommendation applies only to postmenopausal women who are considering hormone therapy for the primary prevention of chronic medical conditions. This recommendation is not about the use of hormone therapy to treat menopausal symptoms, such as hot flashes or vaginal dryness, and it does not apply to women younger than age 50 who have had surgical menopause. This is a D recommendation, which means the USPSTF recommends against the service. There is moderate or high certainty that the service has no net benefit or that the harms outweigh the benefits.