State departments of health and agriculture in several states, collaborating local health jurisdictions, CDC, and the United States Department of Agriculture’s Food Safety and Inspection Service (USDA-FSIS) are investigating a multi-state outbreak of Escherichia coli O157:H7 infections. As of July 15, 2008, 45 confirmed cases have been linked both epidemiologically and by molecular fingerprinting to this outbreak. The number of cases in each state is as follows: Georgia (1), Indiana (1), Kentucky (1), Michigan (20), New York (1), and Ohio (21). Their illnesses began between May 27 and June 24, 2008. Twenty-three persons have been hospitalized. One patient developed a type of kidney failure called hemolytic-uremic syndrome (HUS). No deaths have been reported. Twenty-six (58%) patients are female. Patients range in age from 4 to 78 years with a median age of 19 years.