One to three people die in the United States every year from rabies, usually due to exposures to indigenous rabid bats, skunks, or raccoons, or to exposure to rabid dogs while traveling overseas. For this reason, it is important that rabies be considered in all cases of unexplained encephalitis. Rabies is nearly always fatal once symptoms appear, but it can be prevented almost 100% of the time when postexposure prophylaxis including rabies vaccine and immunoglobulin is administered soon after a rabies exposure occurs.
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